Tulane Cancer Center Members: A
Faculty Membership Application and Membership Definitions
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Abdel-Mageed, Agrawal, Andersson
Asim B. Abdel-Mageed, D.V.M., Ph.D.
Associate Professor of Urology, Adjunct Associate Professor of Pharmacology
Director of Molecular Oncology Research Laboratories
TCC Program Member
amageed@tulane.edu
Faculty listing on Urology website
Curriculum Vitae [PDF] (see also Help with PDF documents)
(504) 988-3634, (504) 988-5059 fax
1430 Tulane Ave., Box SL-42, New Orleans, LA 70112-2699

Biographical Narrative:
Dr. Abdel-Mageed received his D.V.M. from the University of Khartoum, Sudan, in 1983. He was a veterinary practitioner and a faculty member of the Department of Medicine, Pharmacology and Toxicology at the University of Khartoum until 1987. Dr. Abdel-Mageed obtained M.S. (1989) and Ph.D. (1993) degrees in molecular physiology/toxicology at Kansas State University before joining Tulane as a postdoctoral fellow in the Department of Pharmacology with Dr. Krishna Agrawal in 1994. He became a research instructor of pharmacology in 1996, continuing his training in molecular cancer pharmacology. He studied genes associated with breast cancer cell growth and their interaction with nuclear transcription factors to mediate mitogenic responses. In 1997, Dr. Abdel-Mageed joined the faculty as an Assistant Professor in the Department of Urology and adjunct Assistant Professor of Pharmacology. He is founding director of the Molecular Oncology Research Laboratories in the Department of Urology. Dr. Abdel-Mageed has over 25 peer-reviewed publications and has served on several DOD grant review panels. Dr. Abdel-Mageed's laboratory primarily focuses on basic research into the cellular and molecular aspects of urologic diseases, with particular attention given to prostate and bladder cancer. The laboratory has a special interest in tumor cell invasion, metastasis, and disease progression. Molecular biology, genetics, cell biology, and biochemical techniques, as well as studies involving transgenic TRAMP mouse model and in situ analysis of human tissues, are routinely employed to address questions concerning these issues. One area of major interest to Dr. Abdel-Mageed is the role of metallothionein in prostate cancer progression, with special emphasis on cell proliferation using antisense technology and on expression of invasion, angiogenesis and metastasis-related genes using in vitro and in vivo xenograft model systems. He is also examining their expression profile in situ to evaluate their correlation with tumor grade and their potential use as biomarkers for disease progression. More recently, his laboratory has been conducting studies pertaining to isolation and characterization of in vivo differentially expressed genes of prostate cancer as they relate to race, age, and tumor grade using state-of-the-art laser capture microdissection, suppressive subtractive hybridization and DNA microarray technology. Analysis of the expression and function of these genes should allow for a more in depth understanding of the processes controlling prostate cancer cell growth, invasion, and metastasis. Dr. Abdel-Mageed's research interests also include dissection of molecular mechanisms and signaling pathways associated with chemo/radioresistance of prostate cancer. Using a super-repressor I kappa B adenoviral delivery approach, his laboratory is conducting experiments to evaluate the role of inhibiting the activation of the nuclear factor NF-kappa B in enhancing radio/chemosensitization and apoptosis of prostate cancer cells.

Selected Publications:
Krishna C. Agrawal, Ph.D.
Chairman and Regents Professor of Pharmacology
TCC Program Member
agrawal@tulane.edu
Homepage on Pharmacology website:
http://www.som.tulane.edu/departments/pharmacology/Faculty/agrawal.html
(504) 988-5444, (504) 988-1846 fax
1430 Tulane Ave., Box SL-83, New Orleans, LA 70112-2699

Biographical Narrative:
Dr. Agrawal received his Ph.D. in 1965 from the University of Florida. His research interests include mechanisms of drug-induced toxicities, biomarkers, protection of normal tissues from genotoxic agents, growth control, and inhibition of HIV replication.

Selected Publications:
Hans C. Andersson, M.D.
Associate Professor of Human Genetics
TCC Contributing Member
handers@tulane.edu
Homepage: http://www.som.tulane.edu/departments/human_genetics/faculty/andersson.html
(504) 988-5229, (504) 988-7691 fax
1430 Tulane Ave., Box SL-31, New Orleans, LA 70112-2699

Dr. Andersson received his B.S. in Music and Psychology from Tulane in 1978 and received his M.D. from Tulane in 1984. He completed his residency in Pediatrics at the Tulane School of Medicine in 1987. Dr. Andersson also did a fellowship from 1987-1991 at the Hayward Genetics Center and was promoted to Associate Professor in 2000. Dr. Andersson's research focuses on lysosomal storage, inborn errors and medical genetic test reporting.

Selected Publications:

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