Tulane Cancer Center Members: C
Faculty Membership Application and Membership Definitions

---

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Chen, Chiu, Coy

YiPing Chen, Ph.D.
Professor of Cell and Molecular Biology
TCC Associate Member
ychen@tulane.edu
Homepage: www.tulane.edu/~chenhome/index.htm
(504) 865-5587, (504) 865-6785 fax
2000 Stern Hall, 6400 Freret St., New Orleans, LA 70118

Biographical Narrative:
Dr. Chen received his B.S. in Biology in 1982 and M.S. in Developmental Biology in 1985 from Fujian Normal University in China. He then received his Ph.D. in Developmental Biology from the University of Iowa in 1993. After postdoctoral training with his Ph.D. mentor Dr. Michael Solursh at the University of Iowa, he carried out further postdoctoral studies with Dr. Richard Maas at the Harvard Medical School where he was promoted to Instructor in Medicine in 1996. In 1997 Dr. Chen took an Assistant Professor position in the Department of Cell and Molecular Biology, Tulane University. He was promoted to Associate Professor and appointed as Director of Division of Developmental Biology in 2001. Dr. Chen's Research focuses on the genetic control of vertebrate organogenesis. His particular interests include the role of homeobox genes and growth factors in the epithelial-mesenchymal interactions that lead to organ formation. One major project studies molecular mechanisms of tooth initiation and patterning. Currently, the project involves identifying genes involved in vertebrate tooth initiation and their expression regulation, studying the origin of tooth developmental potential, studying the patterning of incisor and molar teeth and genes involved in this process and studying the molecular basis of recombinant tooth formation (a model for tooth regeneration). Dr. Chen's research also studies the molecular basis of non-syndromic cleft palate caused by gene mutations in mammals. Cleft palate is one of the most frequent congenital birth defects in human being. It occurs annually with a frequency of 1 in 700 to 1,000 live births among individuals of European descent. Non-syndromic cleft palate arises from genetic or environmental perturbation in the multi-step process of palate development. Similar to human beings, mutations in the Msx1 gene cause non-sydromic cleft palate in mice. The lab is currently examining the role of Msx1, Dlx1, Dlx2, Bmps, Shh and Fgfs in mouse palatogenesis. Dr. Chen's work includes research on the molecular basis of situs inversus in vertebrate animals. Situs inversus occurs with a frequency of one out of 8,000 live births in humans. It was just recently demonstrated that positioning of internal organs is regulated by a cascade of genetic pathways involving a number of genes. Dr. Chen's lab has been studying the role of transcription factor Pitx2 in the regulation of heart looping. They have recently cloned two novel genes in the chick that show a potential involvement in left-right asymmetric determination during early embryonic development. Functional analyses of these two genes are in progress.

Selected Publications:

• St. Amand TR, Zhang YD, Semina E, Hu YP, Zhao X, Murray J, Chen YP. Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth forming anlage. Dev Biol 217: 323-332 (2000)
• Zhang ZY, Yu XY, Zhang YD, Geronimo B, Lovlie A, Fromm SH, Chen YP. Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation and duplication and posterior transformation of digit in mouse limb. Dev Biol 220: 154-167 (2000)
• Chen YP, Zhang YD, Jiang T-X, Barlow AJ, St. Amand TR, Hu YP, Heaney S, Francis-West P, Chuong C-M, Maas M. Conservation of early odontogenic signaling pathways in Aves. Proc Natl Acad Sci USA 97: 10044-10049 (2000)
• Zhao X, Zhang ZY, Song YQ, Zhang X, Zhang YD, Hu YP, Fromm SH, Chen YP. Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ. Mech Dev 99: 29-38 (2000)
• Yu XY, St. Amand TR, Wang S, Li G, Zhang YD, Hu YP, Nguyen L, Qiu MS, Chen YP. Differential expression and functional analysis of Pitx2 isoforms in regulation of heart looping in the chick. Development 128: 1005-1013 (2001)
• Wang SS, Yu XY, Zhang T, Zhang XY, Zhang ZY, Chen YP. Chick Pcl2 regulates the left- right asymmetry by repressing Shh expression in Hensen's node. Development 131, 4381-4391 (2004)
• Alappat S, Zhang ZY, Suzuki K, Zhang XY, Liu HB, Jiang RL, Yamada G, Chen YP. The cellular and molecular etiology of cleft secondary palate in Fgf10 mutant mice. Dev Biol 277, 102-113 (2005)

Ernest Chiu, M.D.

Degree:
B.A.     University of California at Berkeley, 1989
M.D.    Columbia University College of Physicians and Surgeons, 1995

Residency:
General Surgery, New York University Medical Center, 1998

Fellowship:
Plastic Surgery, NYU Institute of Reconstructive Plastic Surgery, 2003

Research and Clinical Fellowships:
Post-Doctoral Research Fellow, Skirball Biomolecular Institute, NYUMC, 2000
Microsurgery/Breast Reconstruction Fellow, Memorial-Sloan Kettering Cancer Center, 2004

Certification:
American Board of Plastic Surgery, Certified 2005

Clinical Interests:

• Head and Neck Reconstruction
• Aesthetic Surgery
• Breast Reconstruction
• Adipocyte and Bone Marrow Derived Stem Cell Research
• Tissue Engineering
• Vascular and Bone Biology
• Facial Paralysis
• Periorbital Anatomy

Lecture Titles:
2007 Tulane School of Medicine Surgery Grand Rounds
New Orleans, LA                                
 “Microsurgical Oncologic Reconstruction”

2007 Tulane School of Medicine
New Orleans, LA
“Breast Reconstruction”

2007 Tulane School of Medicine Surgery Grand Rounds
New Orleans, LA
“Oncologic Reconstruction using Microsurgical Techniques”

2007 Tulane School of Bioengineering
New Orleans, LA
“Current Application of Biological Scaffolds in Surgery”                       

2008 Aesthetic Facial Reconstruction Meeting
Tucson, AZ
“Head & Neck Oncologic Reconstruction using Supraclavicular Artery Flap”

2008 Southeastern Society Plastic Surgeons Meeting
Boca Raton, FL
“Head & Neck Oncologic Reconstruction using Supraclavicular Artery Flap”

2008 7th International Head and Neck Society Meeting
San Francisco, CA
“Head & Neck Oncologic Reconstruction using Supraclavicular Artery Flap”

Biographical Narrative:
Dr. Chiu received his M.D. in 1995 from Columbia University in New York. He completed his General Surgery residency in 1996 at New York University Medical Center.  Following his General Surgery residency, Dr. Chiu completed a Plastic Surgery residency in 2003 at the Institute of Reconstructive Plastic Surgery in New York. In addition, Dr. Chiu was a post-doctoral research fellow at the Skirball Biomolecular Institute at New York University Medical Center from 1998-2000 as well as completing a fellowship in Microsurgery/Breast Reconstruction at Memorial-Sloan Kettering Cancer Center from 2003-2004.
Dr. Chiu has active ongoing research projects and interests including head and neck reconstruction, adipocyte and bone marrow derived stem cells, tissue engineering, vascular and bone biology, facial paralysis, breast reconstruction, aesthetic surgery, and periorbital anatomy.

Clinic Schedule and Location:
Tulane-Downtown
Plastic Surgery Clinic
1415 Tulane Ave., 6th Floor
New Orleans, LA 70112
Wednesday, 2:00 p.m. – 4:30 p.m.
504-988-1254

Tulane-Downtown
Wound Care Clinic
1415 Tulane Ave., 6th Floor
New Orleans, LA 70112
Every 3rd Monday, 10:00 a.m. – 12:00 p.m.
504-988-1254

Children’s Hospital of New Orleans
Pediatric Plastic Surgery Clinic
200 Henry Clay Ave.
New Orleans, LA 70118
Every 3rd Wednesday, 9:00 a.m. – 12:00 p.m.
504-896-2838 

Recent Publications:

• Granzow, J.W., Levine, J.L., Chiu, E.S., Allen, R.J.  Breast reconstruction with the deep inferior epigastric perforator flap: J Plast Reconstr Aesthet Surg 59(6): 571-9, 2006.

• Granzow, J.W., Levine, J.L., Chiu, E.S., Allen, R.J.  Breast reconstruction with gluteal artery perforator flaps. J Plast Reconstr Aesthet Surg 59(6): 614-21, 2006.

• Chiu, E.S., Jelks, E.B., Capel B., Press, R., Aston, S., Jelks, G.W. Successful management of orbital cellulitis and temporary visual loss after blepharoplasty Plast Reconstr Surg 118(3): 67e-72e, 2006.

• Granzow, J.W., Levine, J.L., Chiu, E.S., Allen, R.J.  Breast Reconstruction using Perforator Flaps.   Journal of Surgical Oncol  94(6): 441-54, 2006.

• Chiu, E.S., Baker, D.C. Endoscopic Forehead Rejuvenation I:  Limitations, Flaws, and Rewards, Letter Reply   Plast Reconstr Surg 119(3): 1115-1117, 2007.

• Gautam, A., Allen, R.J., LoTempio, M.M., Mountcastle, T., Levine, J.L, Allen, R.J., Chiu, E.S. Congenital Breast Deformity Reconstruction using Perforator Flaps. Annals Plast Surg 58(4): 353-358, 2007.

• Chiu, E.S., Allen, R.J.  “Double-pedicle Abdominal Perforator Free Flaps for Unilateral Breast Reconstruction: New Horizons in Microsurgical Tissue Transfer to the Breast.  Discussion” J Plast Reconstr Aesthetic Surg 60(8):913-4, 2007. 

• Bolling, R.P. Sabeeh, V., Stewart, JM, Newsome, R.E., Chiu, E.S., Moses, M. H., Ankyloglossum superius syndrome: diagnosis and surgical management. J Craniofac Surg 18(5): 1094-7, 2007.

• Chiu, E.S., Bravo, F.G., Siebert, J.W. Transverse Thoracodorsal Artery Perforator Flaps: Experience with 31 Free Flaps. J Plast Reconstr Aesthetic Surg, Dec 2007.

• Nelson, P.S., Bourgeois, K.M., Nicotri, T. Chiu, E.S., Poole, J. Sclerosing Sweat Duct Carcinoma in a Six Year-Old African American Child  Pediatric Dermatology 25(1): 38-42, 2008.

• Altman, A.M., Matthias, N., Yan, Y., Song, Y.H., Bai, X. Chiu, E.S., Slakey, D.P., Alt, E.U.  Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells.  Biomaterials 29(10): 1431-1442, 2008.

David H. Coy, Ph.D.
Research Professor of Medicine: Section of Endocrinology
Adjunct Professor of Biochemistry Head of Peptide Research Laboratories
Endowed Chair of Peptide and Protein Research
TCC Program Member
dcoy@tulane.edu
(504) 988-3584, (504) 988-3586 fax
1430 Tulane Ave., Box SL-12, New Orleans, LA 70112-2699

Biographical Narrative:
Dr. Coy received his B.S. in Chemistry in 1966 and Ph.D. in organofluorine chemistry in 1969 from the University of Manchester Institute of Science and Technology. He then did postdoctoral research on neurophysin proteins while working with Dr. Murray Saffran's group at the Medical College of Ohio at Toledo and on the synthesis and medicinal chemistry of hypothalamic peptide hormones while working with Nobel Laureate Dr. Andrew Schally at Tulane. He became Assistant Professor in the Department of Medicine at Tulane in 1973 and Research Professor in 1982. Dr. Coy is the author and co-author of over 600 scientific papers. He is a fellow of the American Association for the Advancement of Science, serves on the editorial boards of several journals and has served on study sections for both the NIH and the Medical Research Council of Canada. Dr. Coy's research group has long been prominent in the area of peptide-based drug development. He holds over 50 patents in the area and has successfully brought two peptide analogs to market. Current research interests include the development of receptor antagonists for the bombesin receptors 1 and 3, which are of potential use in inflammatory lung disease and lung cancer, as well as development of urotensin II antagonists of potential therapeutic value in the cardiovascular area. Dr. Coy's group is also researching the use of peptide agonist analogs, particularly somatostatin and bombesin, for the specific targeting and proactive internalization of cytotoxic agents and anti-sense oncogene constructs into tumor cells which heavily over-express receptors for several families of peptides. His group has the capability of conducting peptide-based drug design by classical structure-activity studies, by computer-based design strategies, and, more recently, by combinatorial synthesis of peptidomimetic libraries. His research has been supported by NIH, private industry and the Tulane Peptide Research Fund.

Selected Publications:

• Tokita K, Hocart SJ, Katsuno T, Mantey SA, Coy DH, Jensen RT. Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368. J Biol Chem 276: 495-504 (2001)
• Rajaswaran WG, Hocart SJ, Murphy WA, Taylor JE, Coy DH. Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist. J Med Chem 44: 1305-1311 (2001)
• Rajaswaran WG, Hocart SJ, Murphy WA, Taylor JE, Coy DH. N-methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity. J Med Chem 44: 1416-1421 (2001)
• Weber HC, Walters J, Leyton J, Casibang M, Purdom S, Jensen RT, Coy DH, Ellis C, Clark G, Moody TW. A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells. "Eur J Pharmacol 412: 13-20 (2001)
• Mantey SA, Coy DH, Pradhan TK, Igarashi H, Rizo IM, Shen L, Hou W, Hocart SJ, Jensen RT. Rational design of a peptide agaonist that interacts selectively with the orphan receptor, bombesin receptor subtype 3. J Biol Chem 276: 9219-9229 (2001)
• Sun L, Vasilevich NI, Fuselier JA, Coy DH. Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice. Anticancer Res 24: 179-186 (2004).
• Sun L, Fuselier JA, Coy DH. Effects of camptothecin conjugated to a somatostatin analog on growth of tumor cell lines in culture and related tumors in rodents. Drug Deliv, 11: 1-8 (2004).

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

---

Return to the top of this page.
Return to the Tulane Cancer Center homepage.

Calendars Clinical Trials Faculty Links Location News
Search Site index