Tulane Cancer Center Members: K
Faculty Membership Application and Membership Definitions
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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Kahn, Karam, Kendall, Korndorffer, Krause, Krogstad, Kruse-Jarres
Marc J. Kahn, M.D.
Professor of Medicine
Section of Hematology and Medical Oncology
Associate Dean for Student Affairs
TCC Contributing Member
mkahn@tulane.edu
(504) 988-5331, (504) 988-6462 fax
1430 Tulane Ave., Box SL-67, New Orleans, LA 70112-2699
Curriculum Vitae (in Adobe Acrobat PDF format; see PDF help)
Jim D. Karam, Ph.D.
Professor and Chairman of Biochemistry
TCC Contributing Member
karamoff@tulane.edu
Homepage on the Biochemistry website:
www.tulane.edu/~biochem/faculty/karam.htm
(504) 988-1995, (504) 988-1611 fax
1430 Tulane Ave., Box SL-43, New Orleans, LA 70112-2699

Biographical Narrative:
Dr. Karam received his B.S. in Biology/Chemistry from the American University of Beirut, Lebanon in 1958. He carried out his doctoral studies in Biochemistry with Dr. Edward Glassman at the University of North Carolina, Chapel Hill, receiving his Ph.D. in 1965. His postdoctoral studies were carried out with Dr. Joseph F. Speyer at the Cold Spring Harbor Laboratory in New York. In 1967 he became Research Assistant Professor of Genetics and Cell Biology at the University of Connecticut at Storrs and in 1968 moved to Sloan-Kettering Institute for Cancer Research in New York City as a Research Associate. In 1971 Dr. Karam joined the faculty at the Medical University of South Carolina where he attained the rank of professor. He was appointed to his current position as Professor and Chair of the Department of Biochemistry in the School of Medicine at Tulane University Health Sciences Center in November, 1991. The primary focus of Dr. Karam's research is on the genetic and biochemical mechanisms that regulate the multiprotein DNA replication machine (DNA replisome) of bacteriophage T4 and the T4-related phages. These bacterial viruses encode all of the proteins required for assembly of the viral replisome and replication of the ~170,000 base-pair (bp) linear and circularly permuted DNA genome. Complexity of the T4 replisome resembles that of many large pathogenic DNA viruses, like the herpes, vaccinia, and adeno viral groups At the core of the T4 DNA replisome is the replicative DNA polymerase, product of phage gene 43 (gp43), which works in a complex with a large number of other proteins to affect rapid and accurate genome replication in the phage-infected Escherichia coli host. T4 gp43 carries several functions in its single polypeptide chain, including two catalytic activities that work together to control fidelity of replicative DNA synthesis. These two activities are the polymerase (DNA synthesizing) activity, which determines fidelity of nucleotide base selection and rate of DNA chain extension, and the editing or proofreading (3'-exonuclease) activity, which removes misincorporated bases. Studies in Dr. Karam's laboratory are determining how these two activities of the enzyme are coordinated to maintain low mutation rates. Other studies are addressing relationships between two types of nucleic-acid binding functions of this DNA polymerase. The nucleotide-sequence independent DNA binding activity used for phage DNA replication and a highly specific RNA binding activity through which the enzyme binds its own mRNA and regulates its own biosynthesis at the level of translation are both being studied. Recent results suggest that this viral enzyme uses RNA as a scaffold to build the multiprotein replisome. Experimental tools are being generated to find out if cellular and other viral DNA polymerases also use specific RNA to initiate replisome assembly.

Selected Publications:
Carl Kendall, Ph.D.
Acting Chairman and Associate Professor of International Health and Development
TCC Contributing Member
ckendall@tulane.edu
(504) 988-3655, (504) 988-3653 fax
1430 Tulane Ave., Box SL-29, New Orleans, LA 70112-2699
Faculty listing on the IHD website:
http://www.tulane.edu/~inhl/faculty.shtml#Carl Kendall

Biographical Narrative:
Carl Kendall, PhD is a Professor and Acting Chair of the Tulane University Department of International Health and Development. Dr. Kendall rejoined Tulane after a two-year sabbatical as the Director of the Maternal and Child Epidemiology Unit at the London School of Hygiene and Tropical Medicine. Prior positions include Chief of the Behavioral Research Unit, AIDS Control and Prevention Project (AIDSCAP), Family Health International and Director, Center for International Community-based Health Research, Department of International Health, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland. Dr. Kendall has served as a member of numerous professional panels related to the AIDS/HIV pandemic and is on the Governing Council of the American Public Health Association. He is a frequent consultant to AIDS/HIV and child health programs in Latin America, Africa and Asia.

James Korndorffer, M.D.
Associate Professor of Surgery
TCC Program Member
jkorndo@tulane.edu
(504) 988-2307
1430 Tulane Ave., Box SL-22, New Orleans, LA 70112-2699

John R. Krause, M.D.
Professor and Chairman of Pathology and Laboratory Medicine
Director of Laboratories
Chief of Clinical Pathlogy
TCC Associate Member
jkrause@tulane.edu
(504) 988-5210, (504) 988-7839 fax
1430 Tulane Ave., SL-79, New Orleans, LA 70112-2699
Homepage on the Pathology website:
http://www.som.tulane.edu/departments/pathology/faculty/krause/krause.html

Biographical Narrative:
Dr. Krause received his B.S. from the Pennsylvania State University in 1962 and his M.D. from the University of Pittsburgh in 1966. He completed his pathology residency and hematopathology fellowship at the University of Pittsburgh Health Center Hospitals from 1966-1971. He has held academic positions at the Medical College of Pennsylvania, the University of Pittsburgh, and, since 1992, Tulane University School of Medicine. Since 1998, he has been Chair, Department of Pathology and Laboratory Medicine. Dr. Krause's research interests are in the field of hematopathology with particular interest in leukemias and lymphomas. Dr. Krause published one of the early books on the importance of the bone marrow biopsy in the evaluation of hematopathology disorders. He has extensive experience in the interpretation of bone marrow and lymph nodes specimens. He has developed and expanded our Flow Cytometry Facility and molecular diagnostic laboratory to aid in the interpretation of these disorders. Dr. Krause's current interests and research lie in the application of molecular techniques for diagnosis of malignant hematopathic neoplasms.

Selected Publications:
Donald J. Krogstad, M.D.
Henderson Professor and Chairman of Tropical Medicine
Director of the Center for Infectious Diseases
TCC Contributing Member
krogstad@tulane.edu
(504) 988-3558, (504) 988-6686 fax
1430 Tulane Ave., Box SL-17, New Orleans, LA 70112-2699

Biographical Narrative:
Dr. Krogstad received his undergraduate degree from Bowdoin College in Brunswick, Maine. He received his M.D. in 1969 from Harvard Medical School. After training at the Massachusetts General Hospital in Boston, he served at the Centers for Disease Control in Atlanta in Parasitic Diseases and as a Peace Corps Volunteer Physician in Lilongwe, Malawi. After serving at the Washington University School of Medicine for 14 years, Dr. Krogstad joined the Tulane faculty in June 1992 as Chair of Tropical Medicine, was invested as the Henderson Professor in 1994, and appointed Director of the Center for Infectious Diseases in 1998. Dr. Krogstad's current research is aimed at the molecular and genetic bases of resistance to chloroquine and quinine, structure-activity relationships among antimalarials, the development of a transfection system in Plasmodium falciparum and the use of plasmid constructs with a proline-rich amino acid linker to enhance the immunogenicity of cloned malaria parasite antigens. Field studies are centered in Mali and focus on three issues: optimal strategies for the use of chloroquine, techniques for the characterization of individual clones from polyclonal field isolates, and the development of methods to study pathogenicity and parasite virulence.

Selected Publications:

Rebecca Kruse-Jarres, M.D.
Assistant Professor of Medicine, Section of Hematology & Medical Oncology
TCC Contributing Member
rkruseja@tulane.edu
(504) 988-5433
1430 Tulane Ave., Box SL-78, New Orleans, LA 70112-2699

Selected Publications:


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