Tulane Cancer Center Members: Z
Faculty Membership Application and Membership Definitions

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Zakris, Zhang

Ellen L. Zakris, M.D.
Clinical Associate Professor of Radiology
TCC Program Member
ezakris@tulane.edu
(504) 988-6308, (504) 988-6362 fax
1430 Tulane Ave., Box HC-62, New Orleans, LA 70112-2699

Biographical Narrative:
Dr.Zakris received her B.A. in Microbiology from Rutgers University in 1983. She received her M.D. from Duke University in 1987. She completed an internship in internal medicine in 1988 at San Rafaels Hospital in Connecticut and completed a residency in radiation therapy at Harvard University from 1988-1992. Dr. Zakris joined the Tulane faculty in 1997 and is currently an Associate Professor of Clinical Radiology. Dr. Zakris' research interests are AIDS-related malignancies, breast cancer, gynecological malignancies, lymphoma, total body irradiation, pediatric oncology, radiosurgery, brachytherapy and total skin electron beam.

Recent Publications:

• Swanton RG, Kuske RR, Hawkins GB, Golodner EH, Bell K, Fidler RY, Zakris EL. (1996) Diagnosis and Treatment of Disseminated Epidemic Kaposi's Sarcoma with Radiation Therapy and Chemotherapy: A Case Study. South Med J 89: 718-722.
• Zakris EL, Kuske RR. (1996) Selected Topics in Breast Cancer: Local Recurrence After Breast Conserving Therapy. Prob Gen Surg 13(1): 119-128.

Haitao Zhang, Ph.D.
Assistant Professor, Department of Pathology & Laboratory Medicine
TCC Program Member
hzhang@tulane.edu
(504) 988-7696
1430 Tulane Ave., Box SL-79, New Orleans, LA 70112-2699

Biographical Narrative:
Dr. Zhang graduated in 1992 from the Department of Biology, Nankai University, with a B.S. in molecular biology. Subsequently, he went to the Institute of Genetics, Chinese Academy of Sciences and completed two years of graduate study. In 1995, he was matriculated into the Ph.D. program in the Department of Experimental Pathology at Roswell Park Cancer Institute. His dissertation project was on cloning and characterization of the human RAG-1 and RAG-2 gene promoters. After receiving his Ph.D. in 2000, Dr. Zhang started to work in the laboratory of Margot Ip, Ph.D., studying the mechanism of TNFalpha suppression of functional differentiation of mammary epithelial cells. In the fall of 1999, he enrolled in the master's program in the Department of Computer Science and Engineering, State University of New York at Buffalo. He continued these studies during his postdoctoral training and graduated in 2001 with a M.S. in computer science. From 2001 - 2002, he worked at the Microarray and Genomics Core Facility at Roswell Park as a bioinformatics specialist. He joined the Department of Cancer Chemoprevention at Roswell Park in 2003 as a research scientist and was promoted to assistant professor there in 2005. He joined the faculty of Tulane University Health Sciences Center as an assistant professor in the Department of Pathology and Laboratory Medicine in January 2008.

Recent Publications:

• Li S, Zhou Y, Wang R, Zhang H, Dong Y, Ip C. Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-akt and its downstream substrates. Molecular Cancer Therapeutics, 6:1031, 2007.
• Zhang H, Wu Y, Malewicz B, Lu J, Li S, Marshall J, Ip C, Dong Y. Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid. Cancer, 107(12): 2942, 2006.
• Wu Y, Zhang H, Dong Y, Park YM, Ip C. A new look into the anticancer mechanism of selenium through the lens of endoplasmic reticulum stress. Cancer Res, 65(19): 9073, 2005.
• Dong Y, Zhang H, Gao AC, Marshall JR, Ip C. Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers. Molecular Cancer Therapeutics, 4(7): 1047, 2005.
• Zhang H, Dong Y, Zhao H, Brooks JD, Hawthorn L, Nowak N, Marshall JR, Gao AC, Ip C. Microarray data mining for potential selenium targets in chemoprevention of prostate cancer. Cancer Genomics and proteomics, 2:97, 2005.
• Park EM, Choi KS, Park SY, Kong ES, Zhang H, Ip C, Park YM. A display thiol-proteomics approach to characterize global redox modification of proteins by selenium: implications for the anticancer action of selenium. Cancer Genomics and Proteomics, 2: 25, 2005.
• Zhang H, Zhang H, Lee L, Ip MM. The LIP isoform of C/EBPbeta, but not NFkappaB, mediates the transcriptional inhibition of beta-casein by tumor necrosis factor-alpha (TNF). Endocrinology, 145: 2833, 2004.
• Dong Y, Lee SO, Zhang H, Marshall JR, Gao AC, Ip C. Prostate specific antigen (PSA) expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res, 64: 19, 2004.
• Dong Y, Zhang H, Hawthorn L, Ganther HE, Ip C. Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array. Cancer Res, 63:52, 2003.

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