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Inside the Tulane Cancer Center June 2004 Newsletter |

Betty Jurisich, R.N., B.S.N., M.P.H.,O.C.N., C.C.R.P.
| On Wednesday, December 3, 2003, the normally quiet parking lot next to St. Joseph's Church on the corner of Tulane Avenue and S. Claiborne became a whirlwind of activity and excitement, as state legislators, members of city government, physicians, cancer survivors, media representatives and the academic leadership, faculty and staff from the LSU and Tulane University health sciences centers met for the ceremonial groundbreaking for the Louisiana Cancer Research Center. This shared 150,000-gross-square-foot facility will occupy this corner and will house the Louisiana Cancer Research Consortium's (LCRC) state-of-the-art equipment and laboratories, as well as the talented cancer researchers from Tulane and LSU who have already joined forces. The center will cost approximately $55 million and will take approximately 15 months to complete once construction begins. |
| Roy S. Weiner, M.D., welcomes Governor Kathleen Blanco to the Groundbreaking Ceremony. |

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Following a lengthy selection process, Hillier Architecture, a nationally recognized design and facilities planning firm with five offices across the country, has been chosen to design the new research building. This firm is uniquely qualified to address the laboratory, scientific and technological requirements for the project, as they have designed several cancer research buildings for other clients in the past. Representatives from Hillier participated recently in two planning retreats with Dr. Weiner and Dr. Oliver Sartor, co-director of the LCRC and director of LSU's Stanley S. Scott Cancer Center, as well as several of the other research scientists who will call the building home. "The purpose of the meetings was to understand the requirements of the researchers who will be working in the building as well as to bring our experience and expertise to the table," said Steve McDaniel, principal architect with Hillier. "Our priorities right now are to design a structure that will yield the maximum amount of research space, as well as promote interaction and optimal collaboration among the researchers from both Tulane and LSU." Other priorities identified at the planning retreats include highly accessible common areas for shared core equipment, creativity in bringing natural light into the building, and "shelled" space that will be outfitted with additional laboratories as the Consortium continues to grow. McDaniel added that Hillier has been charged with fulfilling the vision that this research building is a recruiting tool, a state-of-the art lure for attracting top-notch researchers from all over the world here to New Orleans. Hillier has selected the local architectural firm of Lyons & Hudson to work with them on this project. The Consortium and its new Cancer Research Center is expected to fuel economic development for the city and the state, with a projected five-year financial impact of more than $350 million once the Center is fully operational. More importantly, it will help diversify the state's economy and provide jobs paying considerably more than the Louisiana average wage. It will also provide new career opportunities for graduates of Louisiana universities. |
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Roy S. Weiner, M.D., and Oliver Sartor, M.D., co-directors of the Louisiana Cancer Research Consortium |
| The Consortium was created during the Louisiana State Legislature's 2002 Special Session in a bill introduced by Senator John J. Hainkel, Jr., and is supported by three cents of a 12-cent increase in the tax on a pack of cigarettes introduced by then Rep. (now Lieutenant Governor) Mitch Landrieu during the 2002 Regular Legislative Session. The tax is expected to generate approximately $10 million per year and is dedicated to funding infrastructure and cancer research program development for the new Consortium. "The groundbreaking was a galvanizing event for all supporters of the Consortium," said Weiner, "and I am thrilled to be able to thank them and celebrate our progress in this way. But, I'll be even more thrilled when we gather again for the ribbon-cutting ceremony for the new Louisiana Cancer Research Center!" |
| Senator John J. Hainkel, Jr.; Senator Lambert Boissiere, Jr.; and Senator Diana Bajoie |
With the exception of the immune system and reproductive cells, the same DNA occurs in every cell in our bodies. What then, makes a skin cell act like a skin cell and not a muscle cell or a brain cell? The answer can be found in an area of science called epigenetics.
It's an area in which Melanie Ehrlich, Ph.D., Professor of Biochemistry and Genetics, is a world-renowned expert. "Although the DNA is the same in both the skin and the muscle cells, there are processes that control which genes are turned on or expressed in each cell type and are transmitted from cell to progeny cell," said Ehrlich. "This difference in gene expression among different types of cells is what makes them look and behave differently."
This figure illustrates Southern blotting analysis of some of the 120 ovarian tumors Dr. Ehrlich's lab studied for changes in methylation of a highly repeated DNA sequence (a satellite DNA). A hypomethylation score of 4 for the tumor means the most loss of normal methylation and a score of 0 means normal methylation in the tumor. The normal control tissues show no hypomethylation (hypomethylation score 0), while sperm, which normally has a very low level of methylation in this satellite DNA, has a hypomethylation score of 4 and serves as a hypomethylation standard. In this study of ovarian cancer patients followed for at least 4 years after optimal surgery, patients with hypomethylation scores of 3 or 4 in their tumor DNA tended to have a significantly worse prognosis than those with lower scores. Furthermore, a hypomethylation score of 2 or less was a better predictor of good recovery for ovarian cancer patients than conventional markers .

Roy S. Weiner, M.D.