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S2C10aP4a-Impetigo Herpetiformis

S2C10aP4a-1:The patterns are psoriasiform; focally to the left and also near the center of the field, the epidermal changes are more prominent. Near the center of the field and to the far left, there are pustules .  Rete ridges are regularly elongated. There are perivascular infiltrates of lymphoid cells in the upper portion of the reticular dermis (impetigo herpetiformis).

S2C10aP4a-2: At higher magnification, a subcorneal pustule is associated with infiltrates of inflammatory cells among keratinocytes of the underlying epidermis. Spaces among the keratinocytes are widened.

S2C10aP4a-3: There is a well-developed intra-epidermal and subcorneal pustule in the center of the field. The neighboring epidermis shows psoriasiform patterns. There are minimal changes in the keratin layer over the pustule.

S2C10aP4a-4: At this margin of one of the pustules, there are irregular defects among keratinocytes of the superficial unit of the epidermis. The defects are outlined by remnants of  the walls of keratinocytes that mostly have undergone lysis. Neutrophils have collected in the intra-epidermal defects and in the subcorneal pustule. The pattern in this field is that of a spongioform pustule; the changes are of a type seen in lesions of pustular psoriasis. This example is from a patient with the clinical picture of impetigo herpetiformis.

S2C10aP4a-5: At the opposite side of the pustule, lytic defects among keratinocytes are small and fairly uniform; the pattern is that of a spongioform pustule.

 

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