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S7C1 - VESICULO-BULLOUS DISORDERS (2)
SECTION 7
CHAPTER 7-HOME
Richard J. Reed, New Orleans, LA 70125, 10 Jul 05
You are at Section 7, Chapter1, a section devoted to a discussion of a variety of vesiculo-bullous disorders, including sub- and intra-epidermal vesiculo-bullous
disorders such as herpes (pemphigoid) gestationis, linear IgA dermatitis, pemphigus, incontinentia pigmenti, and hydroa aestivale, among others. The conventions, which hold for the preceeding sections, have the same
application for this section. Clusters of navigation bars are present in the MASTERBORDER to the left and at the end of each page. The blue
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There are three additional navigation bars. One of these bars (UP) provides access to parent textual chapters at the second level, if the reader is at the
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VESICULO-BULLOUS DISEASES (II)
In this section, some of the uncommon bullous disorders, or uncommon patterns in more common bullous disorders, are discussed. In the category of the subepidermal
bullous disorders, the ultrastructural units at the basement membrane level (that zone at the dermal-epidermal interface in which structural components from the epidermis and the dermis are integrated to bind the
epidermis to the dermis) are complex; they are antigenically diverse. Many of the structural, antigenic components have a role in the histogenesis of certain diseases. In some of the bullous disorders, the
attachment of antibodies to one or more of the antigenic structures results in the activation of the complement system. In the ensuing cascade, inflammatory mediators diffuse among the structures of the basement
membrane zone; they produce lysis of structural components and also may damage basal keratinocytes. Eventually, the epidermis and dermis separate. The site of antibody-antigen interaction is best studied beyond the
domain of the bulla. In the site of the bulla, the complement cascade will have significantly altered the structural components of the basement membrane area.
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