Research in my laboratory focuses on a number of aspects of retroviral pathogenesis. We have found that HIV induces a number of defects in plasma membrane ion transport which could account for the loss of CD4+ T-cells in AIDS patients. Another interest is the molecular characterization an isolate of HIV from a patient who died of AIDS in 1969. This is the earliest confirmed case of AIDS in the United States. In addition, we have discovered a retrovirus named human intracisternal A-type retroviral particle (HIAP) which appears to be involved in systemic autoimmune diseases and idiopathic CD4 T-lymphocytopenia. More recently, we obtained evidence for the existance of a human endogenous retrovirus, named human mammary tumor virus (HMTV), which is a close homolog of a virus which causes breast cancer in mice. 

Sainz, B. Jr., E. C. Mossel, C. J. Peters, and R. F. Garry. 2004. Interferon-_eta and interferon-gamma synergistically inhibit replication of severe acute respiratory syndrome-associated coronavirus. Virol. 329, 11-17. Abstract

Jaspan, H.B., J. E. Robinson, A. M. Amedee, R. B. Van Dyke, and R. F. Garry. 2004. Neutralizing antibody to HIV-1 and SIV in amniotic fluid.  J. Clin. Virol. 31, 190-197. Abstract

Prabhu, R. N. Khalap, R. Burioni, M. Clementi, R. F. Garry and S. Dash. 2004. Inhibition of hepatitis C virus nonstructural protein, helicase activity, and viral replication by a recombinant human antibody clone. Am. J. Path. 165, 1163-73. Abstract

Garry, C. E., Garry R. F. 2004. Proteomics computational analyses suggest that the carboxyl terminal glycoproteins of Bunyaviruses are class II viral fusion proteins (beta-penetrenes). Theor. Biol. Med. Model 1,10. Abstract

Sainz, B. Jr., J. M. Rausch, W. R. Gallaher, R. F. Garry and W. C. Wimley. 2005. The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: putative role during viral entry. Biochemistry 44,947-958. Abstract

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