Dr. Holland's influence in glaucoma research enabled a Tulane resident to publish a signal paper. Dr. William A. Hubbard was able to perform a research project in conjunction with the Merck Sharp & Dohme company, testing a novel glaucoma agent. The drug was timolol, and Dr. Hubbard published the very first article in the world literature on human IOP reduction by timolol. This article appeared in Investigative Ophthalmology, 15(6):489-92, 1976. Timolol became the most important advancement in medical glaucoma treatment in decades.
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