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Asim
Abdel-Mageed, D.V.M., M.S., Ph.D.
Associate
Professor of Urology and Director of Molecular Urology and Oncology
Research Laboratories; Adjunct Professor of Pharmacology
Dr. Abdel-Mageed received his D.V.M. from the University of Khartoum , Sudan, in 1983. He was a veterinary practitioner and a faculty member of the Department of Medicine, Pharmacology and Toxicology at the University of Khartoum until 1987. Dr. Abdel-Mageed obtained M.S. (1989) and Ph.D. (1993) degrees in molecular physiology/toxicology at Kansas State University before joining Tulane as a postdoctoral fellow in the Department of Pharmacology with Dr. Krishna Agrawal in 1994. He became a research instructor of pharmacology in 1996, continuing his training in molecular cancer pharmacology. He studied genes associated with breast cancer cell growth and their interaction with nuclear transcription factors to mediate mitogenic responses. In 1997, Dr. Abdel-Mageed joined the faculty as an Assistant Professor in the Department of Urology and adjunct Assistant Professor of Pharmacology . He is founding director of the Molecular Oncology Research Laboratories in the Department of Urology. Dr. Abdel-Mageed has over 25 peer-reviewed publications and has served on several DOD grant review panels. Dr. Abdel-Mageed's laboratory primarily focuses on basic research into the cellular and molecular aspects of urologic diseases, with particular attention given to prostate and bladder cancer. The laboratory has a special interest in tumor cell invasion, metastasis, and disease progression. Molecular biology, genetics, cell biology, and biochemical techniques, as well as studies involving transgenic TRAMP mouse model and in situ analysis of human tissues, are routinely employed to address questions concerning these issues. One area of major interest to Dr. Abdel-Mageed is the role of metallothionein in prostate cancer progression, with special emphasis on cell proliferation using antisense technology and on expression of invasion, angiogenesis and metastasis-related genes using in vitro and in vivo xenograft model systems. He is also examining their expression profile in situ to evaluate their correlation with tumor grade and their potential use as biomarkers for disease progression. More recently, his laboratory has been conducting studies pertaining to isolation and characterization of in vivo differentially expressed genes of prostate cancer as they relate to race, age, and tumor grade using state-of-the-art laser capture microdissection, suppressive subtractive hybridization and DNA microarray technology. Analysis of the expression and function of these genes should allow for a more in depth understanding of the processes controlling prostate cancer cell growth, invasion, and metastasis. Dr. Abdel-Mageed's research interests also include dissection of molecular mechanisms and signaling pathways associated with chemo/radioresistance of prostate cancer. Using a super-repressor I kappa B adenoviral delivery approach, his laboratory is conducting experiments to evaluate the role of inhibiting the activation of the nuclear factor NF-kappa B in enhancing radio/chemosensitization and apoptosis of prostate cancer cells. |
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