Matthew E. Burow, Ph.D.
LaboratoryMission
Matthew E. Burow, Ph.D.Dr. Burow's primary research interests focus on understanding the molecular mechanisms that control estrogen receptor- mediated gene expression and anti-estrogen resistance in breast carcinoma cells and the way that cell survival and apoptotic signaling pathways regulate the progression of breast carcinoma to a hormone-independent and drug-resistant phenotype.
mburow@tulane.edu
(504) 988-6688, fax (504) 588-5483
1430 Tulane Ave., Box SL-78,
New Orleans, LA 70118
Assistant Professor of Medicine: Hematology/Oncology
Adjunct Assistant Professor of Surgery
Tulane Cancer Center Program Member
Lab Members
Steven Elliot
Yun Zhu
Virgilio Alberto Salvo
Selected Publications
• Burow ME, Weldon CB, Collins-Burow BM,
Ramsey N, McKee A, Klippel A, McLachlan JA, Clejan S, Beckman BS. (2000) Cross-talk
between phosphatidylinositol-3 kinase and sphingomyelinase pathways as a
mechanism for cell survival/death decisions. J Biol Chem 275(13): 9628-9635.
• Burow ME, Weldon CB, Melnik LI, BN Duong, Collins-Burow BM, Klippel A, Beckman BS, McLachlan JA. (2000) Phosphatidylinositol 3-kinase/AKT mediated regulation of NF-_B signaling events as a mechanism for suppression of TNF-induced apoptosis. Biochem and Biophys Res Comm 271: 342-345.
• Burow ME, Boue BS, Collins-Burow BM, Melnik LI, Duong BN, Li SF, Wiese T, Cleavland E, McLachlan JA. (2001) Phytochemical glyceollins, isolated from soy, mediate anti-hormonal effects through estrogen receptor alpha and beta. J Clin Endocrinol Metab 86(4): 1750-1758.
• Burow ME, Weldon CB, Tang Y, McLachlan JA, Beckman BS. (2001) Oestrogen-mediated suppression of TNF-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by anti-oestrogens. J Steroid Biochem Mol Bio 78(5): 409-418.
• Frigo DE, Duong BN, Melnik LI, Schief L, Collins-Burow BM, Pace DK, McLachlan JA, Burow ME. (2002) Flavonoid Phytochemicals Regulate Activator Protein-1 Signal Transduction Pathways in Endometrial and Kidney Stable Cell Lines. J Nutrition 132(7): 1848-1853.
• Burow ME, Weldon CB, Melnik LI, BN Duong, Collins-Burow BM, Klippel A, Beckman BS, McLachlan JA. (2000) Phosphatidylinositol 3-kinase/AKT mediated regulation of NF-_B signaling events as a mechanism for suppression of TNF-induced apoptosis. Biochem and Biophys Res Comm 271: 342-345.
• Burow ME, Boue BS, Collins-Burow BM, Melnik LI, Duong BN, Li SF, Wiese T, Cleavland E, McLachlan JA. (2001) Phytochemical glyceollins, isolated from soy, mediate anti-hormonal effects through estrogen receptor alpha and beta. J Clin Endocrinol Metab 86(4): 1750-1758.
• Burow ME, Weldon CB, Tang Y, McLachlan JA, Beckman BS. (2001) Oestrogen-mediated suppression of TNF-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by anti-oestrogens. J Steroid Biochem Mol Bio 78(5): 409-418.
• Frigo DE, Duong BN, Melnik LI, Schief L, Collins-Burow BM, Pace DK, McLachlan JA, Burow ME. (2002) Flavonoid Phytochemicals Regulate Activator Protein-1 Signal Transduction Pathways in Endometrial and Kidney Stable Cell Lines. J Nutrition 132(7): 1848-1853.
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Tulane
School of Medicine, Tulane Department
of Medicine,
Section of Hematology
and Medical Oncology,
Tulane Cancer Center