Education
B.A. Johns Hopkins University, 1982
Ph.D. Duke University, 1988
Research Interests
Regulation of lung inflammation and injury by sensory neuropeptides; tumor necrosis factor and chronic obstructive pulmonary disease; environmental lung disease; transgenic mouse models of lung disease
Recent Publications
Lee, C.-T., Ylostalo, J., Friedman, M., and Hoyle, G. W. (2005). Gene expression profiling in mouse lung following polymeric hexamethylene diisocyanate exposure. Toxicol. Appl. Pharmacol. 205:53-64.
Lee, C.-T., Poovey, H. G., Rando, R. J., Friedman, M., and Hoyle, G. W. (2003). An HDI polyisocyanate aerosol exposure system for large-scale animal experiments. Am. Ind. Hyg. Assoc. J. 64:439-444.
Lee, C.-T., Friedman, M., Poovey, H. G., Ie, S. R., Rando, R. J., and Hoyle, G. W. (2003). Pulmonary toxicity of hexamethylene diisocyanate aerosols in mice. Toxicol. Appl. Pharmacol. 188:154-164.
Zhuo, Y., Hoyle G. W., Zhang, J., Morris, G., and Lasky, J. A. (2003). A novel murine PDGF-D splicing variant results in significant differences in peptide expression and function. Biochem. Biophys. Res. Commun. 308:126-132.
Hoyle, G. W. (2003). Neurotrophins and lung disease. Cytokine Growth Factor Rev. 14:551-558.
Vuillemenot, B. R., Rodriguez, J. F., and Hoyle, G. W. (2004). Lymphoid tissue and emphysema in the lungs of transgenic mice inducibly expressing TNF-. Am. J. Resp. Cell Mol. Biol. 30:438-448.
Henson, M. C., Swan, K. F., Edwards, D. E., Hoyle, G. W., Purcell, J., and Castracane, V. D. Leptin receptor expression in fetal lung is enhanced in late gestation in the baboon: a model for human pregnancy. (2004). Reproduction 127:87-94.
Quarcoo, D., Schulte-Herbruggen, O., Lommatzsch, M., Schierhorn, K., Hoyle, G. W., Renz, H., and Braun, A. (2004). Nerve growth factor induces increased airway inflammation via a neuropeptide-dependent mechanism in a transgenic animal model of allergic airway inflammation. Clin. Exp. Allergy 34:1146-1151.
Curiel, T. J., Cheng, P., Mottram, P., Alvarez, X., Moons, L., Evdemon-Hogan, M., Wei, .S, Zou, L., Kryczek, I., Hoyle, G., Lackner, A., Carmeliet, and P., Zou, W. (2004). Dendritic cell subsets diferentially regulate angiogenesis in human ovarian cancer. Cancer Res. 64:5535-5538.
Li, J., Poovey, H. G., Rodriguez, J. F., Brody, A. R., and Hoyle, G. W. (2004). Effect of platelet-derived growth factor on the development and persistence of asbestos-induced fibroproliferative lung disease. J. Environ. Path. Toxicol. Oncol. 23:253-266.
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